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Building plausible futures: Scenario-based strategic planning of industrial development of Kyrgyzstan by Strelkovskii, Nikita; Komendantova, Nadejda; Sizov, Sergey; Rovenskaya, Elena is a Environmental Science article available to read on EtoBox.

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Isoform E2 of drebrin, an actin-binding protein originally identified in neuronal cells, has recently been identified in diverse non-neuronal cells, mostly in association with cell processes and intercellular junctions. Here, we report on the presence of drebrin in normal human skin, epithelial skin cancers, and cultured keratinocytes. Keratinocytes of normal epidermis contain almost no drebrin but the protein is readily seen in hair follicles. By immunohistochemistry and immunoblot, basal cell carcinomas (BCC) are rich in drebrin, and confocal laser scanning and immunoelectron microscopy show accumulation at adhering junctions, in co-localization with actin and partially with plaque proteins. In squamous cell carcinomas, keratoacanthomas, and in epidermal precancers, drebrin is heterogeneously distributed, appearing as mosaics. Primary keratinocyte cultures contain significant amounts of drebrin enriched at adhering junctions. When epithelium-derived cells devoid of drebrin are transfected with drebrin-enhanced green fluorescent protein, constructs accumulate in the cell periphery, and immunoprecipitation shows complexes with actin. During epidermal growth factor induced formation

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Author

Strelkovskii, Nikita; Komendantova, Nadejda; Sizov, Sergey; Rovenskaya, Elena

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0016-3287)

Published

2020

Language

EN

Field

Environmental Science (Physical Sciences)