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Natural regulatory T cells (Tregs) mature and migrate from the thymus where they constitute 5-10% of peripheral T cells. They express the cell-surface marker CD25 and transcriptional repressor FOXP3. Other antigen-specific regulatory T cells can be induced in the periphery by semi-mature dendritic cells, IL-10, TGF-β, and IFN-γ. These inducible regulatory T cells include TR1 cells that secrete high levels of IL-10 and TH3 cells that secrete high levels of TGF-β. Tregs interact with dendritic cells to mainta
- Author
- cha
- Language
- EN