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Development of Novel Formulation for Sustained Release of Drug to Prevent Swainsonine-Containing Plants Poisoning in Livestock by Bo Li; Congsheng Zhang; Yiru Zhu; Pinzhi Sun; Shangrui Fan; Weina Wang; Yanan Tian; Hao Lu is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Development of Novel Formulation for Sustained Release of Drug to Prevent Swainsonine-Containing Plants Poisoning in Livestock about?
## Simple Summary Swainsonine-containing plants are a poisonous plant widely distributed in grasslands around the world, poisoning by it can cause livestock deaths and economic losses to herdsmen. We have developed a sustained-release injection for the prevention of poisoning by swainsonine-containing plants. Compared to other formulation, e.g., powders and pills, injections have the advantage of convenient administration with easy dosage control. The injection uses poloxamer as the sustained-release matrix and can be solidified into a gel at physiological temperature. We have shown that this formulation is safe and can maintain an effective blood drug concentration for up to 5 days, providing a new approach for preventing swainsonine-containing plants poisoning livestock. ## Abstract Swainsonine-containing plants contain swainsonine which has been shown to cause neurological signs and pathological changes in farm animals. It causes a large number of livestock poisonings every year resulting in economic losses to the livestock industry. At present, “Jifang E” is used in the prevention of swainsonine-containing plants poisoning livestock, and the preventive effects have been well-do
Who reads Development of Novel Formulation for Sustained Release of Drug to Prevent Swainsonine-Containing Plants Poisoning in Livestock?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Bo Li; Congsheng Zhang; Yiru Zhu; Pinzhi Sun; Shangrui Fan; Weina Wang; Yanan Tian; Hao Lu
- Publisher
- MDPI AG
- Published
- 2023
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)