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20(S)‐ginsenoside Rg3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain by Jingwei Tian; Shumin Zhang; Guisheng Li; Zhifeng Liu; Benming Xu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Ginseng, the root of __Panax ginseng__ C.A. Meyer (__Araliaceae__), is a well‐known traditional Chinese herbal medicine. Ginsenosides, which are triterpene derivatives that contain sugar moieties, are the main active ingredients of ginseng. 20(S)‐Ginsenoside Rg3, a triterpene glycoside which chemically belongs to the protopanaxadiol ginsenoside group, is effective in attenuating brain infarction after cerebral ischemia, but the detailed mechanism is not known. This study examined the effect of 20(S)‐ginsenoside Rg3 on mitochondrial permeability transition pore (MPTP) in the rat brain. 20(S)‐Ginsenoside Rg3 at 2–16 μm inhibited Ca^2+^‐ and H~2~O~2~‐induced swelling of mitochondria isolated from rat brains. The addition of Ca^2+^ generated reactive oxygen species (ROS) in isolated mitochondria. 20(S)‐Ginsenoside Rg3 (2–16 μm) inhibited Ca^2+^ induced generation of ROS. At the same time, 20(S)‐ginsenoside Rg3 significantly improved mitochondrial energy metabolism, enhanced ATP levels and the respiratory control ratio. These results suggest that 20(S)‐ginsenoside Rg3 inhibits the opening of MPTP by free radical scavenging action in the brain, and this implies that inhibitio

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Author

Jingwei Tian; Shumin Zhang; Guisheng Li; Zhifeng Liu; Benming Xu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)