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Phenylephrine Induces Endogenous Noradrenaline Release in the Rat Vas deferens through Nitric Oxide Synthase Pathway by Rui Pinto; Clara Barrento; Helder Mota-Filipe; Beatriz Silva Lima is a Medicine article available to read on EtoBox.

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**Abstract:** We have previously observed that in the rat __vas deferens__ nitric oxide synthase pathway potentiated phenylephrine‐induced contractility raising the possibility of a facilitatory role on neurotransmission by nitric oxide. To confirm this hypothesis we studied the effect of phenylephrine on the concentration response curves obtained in preparations from reserpine‐treated rats in the absence and presence of the nitric oxide synthase inhibitor N^G^‐monomethyl‐L‐arginine (L‐NMMA). The endogenous noradrenaline released by normal preparations (without reserpine) was measured in the perfusion fluid of preparations stimulated with phenylephrine, in the absence and presence of L‐NMMA, L‐NMMA + the nitric oxide donor 3‐morpholinosydnonimine hydrochloride (SIN‐1), the α~1~‐adrenoceptor antagonist prazosin and the blocker of noradrenaline carrier desipramine. The phenylephrine‐induced noradrenaline release in a calcium‐free medium was also measured. L‐NMMA decreased the E~max~ of phenylephrine concentration response curves obtained in preparations from normal (reserpine‐untreated) but not from reserpine‐treated rats. In the perfusion fluid of preparations incubated with phenyle

Who reads Phenylephrine Induces Endogenous Noradrenaline Release in the Rat Vas deferens through Nitric Oxide Synthase Pathway?

Author

Rui Pinto; Clara Barrento; Helder Mota-Filipe; Beatriz Silva Lima

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0901-9928)

Published

2003

Language

EN

Field

Medicine (Life Sciences)