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Can I read Microdialysis and Nanofiltration Allow to Distinguish Molecularly Dissolved from Colloid-associated Drug Concentrations During Biomimetic Dissolution Testing of Supersaturating Formulations on EtoBox?
Microdialysis and Nanofiltration Allow to Distinguish Molecularly Dissolved from Colloid-associated Drug Concentrations During Biomimetic Dissolution Testing of Supersaturating Formulations by Florentin Lukas Holzem; Jeannine Petrig Schaffland; Martin Brandl; Annette Bauer-Brandl; Cordula Stillhart is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Microdialysis and Nanofiltration Allow to Distinguish Molecularly Dissolved from Colloid-associated Drug Concentrations During Biomimetic Dissolution Testing of Supersaturating Formulations about?
Many new drug entities are poorly water-soluble and thus require solubility-enhancing formulations to ensure sufficient bioavailability. On the other hand, it is more and more accepted that not all "dissolved" states of a drug contribute equally to enhanced absorption, i.e. an increase in apparent solubility does not necessarily go in parallel with an increase in molecularly dissolved drug, the latter being regarded as the key driving force for absorption. Our study aimed to provide time-resolved information on the dissolution, supersaturation, and precipitation behavior of molecularly dissolved drug as released from an amorphous solid dispersion and a surfactant-containing crystalline suspension of Posaconazole (PCZ), a weakly basic and poorly water-soluble drug. Thereby, we aimed to gain a deeper mechanistic understanding of enabling formulation principles and possibly establish a dynamic biopharmaceutical assessment tool for molecularly dissolved drug released from enabling formulations. A two-staged dissolution test, with media transition from simulated gastric fluid (SGF) to fasted state simulated intestinal fluid (FaSSIF), was performed with three alternative sampling approac
Who reads Microdialysis and Nanofiltration Allow to Distinguish Molecularly Dissolved from Colloid-associated Drug Concentrations During Biomimetic Dissolution Testing of Supersaturating Formulations?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Florentin Lukas Holzem; Jeannine Petrig Schaffland; Martin Brandl; Annette Bauer-Brandl; Cordula Stillhart
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)