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Potentiometric and Spectrofluorimetric Studies on Complexation of Tenoxicam with Some Metal Ions by Horria A. Mohamed; Hanaa M.A. Wadood; Othman A. Farghaly is a Chemistry article available to read on EtoBox.

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The interaction of tenoxicam with six metal ions, viz. Fe(III), Bi(III), Sb(III), Cr(III), Cd(II) and Al(III) was studied using potentiometric and fluorimetric methods. In the potentiometric method the ionization constant of the ligand and stability constants of the complexes formed have been tabulated at 25 90.1 °C, ionic strength of NaNO 3 in 50% (v/v) aqueous acetonitrile solution was 0.05 mol dm -3 . Complexes of 1:1 and/or 1:2 and/or 1:3 metal to ligand ratios are formed. The fluorescence of tenoxicam in the presence and absence of the metal ions was studied. The drug can be determined fluorimetrically in 0.5 M HNO 3 at an emission wavelength of 450 nm (excitation at 350 nm). The linear range is 0.040-0.2 mg/ml in the absence of Al(III) and 0.016-0.1 mg/ml in the presence of Al(III). Tenoxicam was determined by the proposed method in tablet, suppository and injection. The recovery percent ranged from 98.16 to 102.22%. The effect of 2-aminopyridine on the recovery of tenoxicam was also investigated.

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Author

Horria A. Mohamed; Hanaa M.A. Wadood; Othman A. Farghaly

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)

Published

2002

Language

EN

Field

Chemistry (Physical Sciences)