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Quantitative Determination of Albendazole and Its Main Metabolites in Plasma by Juan José Garcia; Francisco Bolás-Fernández; Juan José Torrado is a Chemistry article available to read on EtoBox.

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Three different and complementary chromatographic methods are described for quantitative determination of albendazole (ABZ) and its two main metabolites: albendazole sulphoxide (SOABZ) and albendazole sulphone (SO ABZ). ABZ, SOABZ 2 and SO ABZ can be quantified by two RP-HPLC methods with an ODS2 column and two different mobile phases. One of 2 methanol-water (60:40) for ABZ and a second one of phosphoric acid in water-acetonitrile (80:20) for SOABZ and SO ABZ. SOABZ bears an asymmetric sulphur centre. Quantitative assay of (1) SOABZ and (2) SOABZ can be 2 performed by HPLC. A chiral AGP column and a mobile phase of sodium phosphate buffer (8 mM, pH 7.0) containing different amounts of 2-propanol between 0 to 2% were used. Pharmacokinetic characteristics of ABZ following oral administration of a liquid formulation of ABZ (12 mg / kg) in mice has been studied with these three complementary HPLC methods and the results are reported.

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Author

Juan José Garcia; Francisco Bolás-Fernández; Juan José Torrado

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-4347)

Published

1999

Language

EN

Field

Chemistry (Physical Sciences)