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Local cerebral glucose utilization after D1 receptor stimulation in 6-OHDA lesioned rats: Effect of sensitization (priming) with a dopaminergic agonist by Micaela Morelli; Francesco E. Pontieri; Italo Linfante; Francesco Orzi; Gaetano Di Chiara is a Neuroscience article available to read on EtoBox.

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## Abstract In rats bearing unilateral 6‐hydroxydopamine (6‐OHDA) lesions of the dopaminergic nigro‐striatal neurons, a single administration of a D‐2 agonist (LY 17155) potentiates the contralateral turning induced by a D‐1 agonist (SKF 38393). To identify the neural substrate of this form of sensitization (priming), we studied the local cerebral glucose utilization (lCMR~glc~) in 6‐OHDA lesioned animals treated, 3 days apart, as follows: (1) saline‐saline, (2) LY 171555‐saline, (3) saline‐SKF 38393 and (4) LY 171555‐SKF 38393. The unilateral 6‐OHDA lesion per se (Sal‐Sal) produced increases in lCMR~glc~ in the globus pallidus (GP) and in the lateral habenula (LH) of the lesioned hemisphere. lCMR~glc~ in LY‐Sal group were similar to those measured in the Sal‐Sal group. Administration of SKF 38393 to drug‐naïve rats (Sal‐SKF) abolished the lesion‐induced metabolic asymmetry in the LH but did not have any effect on the GP; furthermore, it increased lCMR~glc~ in the substantia nigra pars reticulata (SNr) of the lesioned side. After priming with LY 171555, administration of SKF 38393 (LY‐SKF) produced marked metabolic asymmetries by increasing lCMR~glc~ in the SNr and entopeduncular n

Who reads Local cerebral glucose utilization after D1 receptor stimulation in 6-OHDA lesioned rats: Effect of sensitization (priming) with a dopaminergic agonist?

Author

Micaela Morelli; Francesco E. Pontieri; Italo Linfante; Francesco Orzi; Gaetano Di Chiara

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

1993

Language

EN

Field

Neuroscience (Life Sciences)