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Effect of crocin on morphine tolerance and serum BDNF levels in a rat model of neuropathic pain by Hossein Ali Safakhah; Farkhondeh Damghanian; Ahmad-Reza Bandegi; Hossein Miladi-Gorji is a Neuroscience article available to read on EtoBox.

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## Background: Chronic use of morphine treatment for neuropathic pain leads to morphine-induced analgesic tolerance. crocin contained in crocus sativus l., exerts anti-inflammatory and analgesic effects. this study examined the effects of crocin on morphine tolerance and serum bdnf levels on neuropathic pain induced by chronic constriction injury (cci) in rats. ## Methods: Cci model of neuropathic pain was done in male wistar rats (200-250 g). rats were treated with crocin (15 or 30 mg/kg, intraperitoneally) alone or simultaneously with morphine (10 mg/kg, subcutaneously) during or after induction of cci. pain behavioral responses including mechanical allodynia and thermal hyperalgesia were measured from days of 15-27 after cci. then, rats were evaluated for serum bdnf levels on days 14 and/or 27. ## Results: We found that morphine tolerance developed after the induction of neuropathic pain. the injection of crocin (15 and 30 mg/kg) was able to enhance analgesic effect of morphine by reduction of mechanical allodynia on days 15-27 post-surgery in cci rats. while preemptive administration of crocin at a lower dose (15 mg/kg) maintained the analgesic effect of morphine. morphine inje

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Author

Hossein Ali Safakhah; Farkhondeh Damghanian; Ahmad-Reza Bandegi; Hossein Miladi-Gorji

Publisher

Elsevier ; Elsevier BV; Springer Science and Business Media LLC (ISSN 1734-1140)

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)