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Capillary plexus development in the day five to day six chick chorioallantoic membrane is inhibited by cytochalasin D and suramin by Goar Melkonian; Nicole Munoz; Jeanne Chung; Cathy Tong; Rebecca Marr; P. Talbot is a Environmental Science article available to read on EtoBox.
What is Capillary plexus development in the day five to day six chick chorioallantoic membrane is inhibited by cytochalasin D and suramin about?
## Abstract The chick chorioallantoic membrane (CAM) is a valuable model for evaluating angiogenesis and vasculogenesis. Our purpose was to characterize the formation of the CAM vasculature, in particular the capillary plexus, between days five and six after fertilization and to examine the mode of action of cytochalasin D and suramin on vascular development during this interval. The CAM increased 20‐fold in size between days five and six, during which time the capillary plexus forms by both migration of mesodermal blood vessels toward the ectoderm and by the formation of new vessels from angioblasts near the ectoderm. Between days five and six, the CAM becomes thinner, and the density of the mesodermal cells decreases. To determine the mode of action of anti‐angiogenic drugs on the day five to day six CAM, various concentrations of cytochalasin D or suramin were added directly to day five CAMs, and their effects were evaluated on day six. Both drugs significantly inhibited CAM growth, altered branching patterns of the major vessels, decreased area of the major vessels, and inhibited the formation of the capillary plexus by inhibiting both vasculogenesis and the migration of mesode
Who reads Capillary plexus development in the day five to day six chick chorioallantoic membrane is inhibited by cytochalasin D and suramin?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Goar Melkonian; Nicole Munoz; Jeanne Chung; Cathy Tong; Rebecca Marr; P. Talbot
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-104X)
- Published
- 2002
- Language
- EN
- Field
- Environmental Science (Life Sciences)