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Comparative analysis of the impact of risk profile and of drug therapy on survival in CML using Sokal's index and a new score by R. Hehlmann; H. Ansari; J. Hasford; H. Heimpel; D. K. Hossfeld; H. J. Kolb; H. Löffler; H. Pralle; W. Queisser; A. Reiter; A. Hochhaus is a Medicine article available to read on EtoBox.
What is Comparative analysis of the impact of risk profile and of drug therapy on survival in CML using Sokal's index and a new score about?
Survival times in chronic myeloid leukaemia (CML) may vary widely depending on the risk profiles of patients. This fact is frequently not, or not sufficiently, considered in evaluating survival in CML, and some studies do not report risk profiles. Therefore we analysed the relative impact of risk profile and therapy on survival using the median survival times of therapy groups and of risk groups of the three‐arm randomized German CML Study I (interferon alpha __v__ hydroxyurea __v__ busulphan; median survival times 65 __v__ 56 __v__ 45 months, __n__=490, median observation time 70.4 months). The impact of risk profile (Sokal) on survival as determined by the survival difference between high and low risk patients (40 months) was twice the maximum survival difference between treatment groups (20 months). A similar ratio was obtained after stratification for therapy and for risk profile. Since Sokal's index has been reported to prognostically discriminate IFN‐treated patients less well than chemotherapy‐treated patients, a new score with better discrimination of IFN‐treated patients was also used. The results were similar for both scores. We conclude that the risk profile at diagnosis
Who reads Comparative analysis of the impact of risk profile and of drug therapy on survival in CML using Sokal's index and a new score?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- R. Hehlmann; H. Ansari; J. Hasford; H. Heimpel; D. K. Hossfeld; H. J. Kolb; H. Löffler; H. Pralle; W. Queisser; A. Reiter; A. Hochhaus
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)