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Grath et al. present a novel method for reprogramming adult human dermal fibroblasts into vascular endothelial cells (rECs) by co-expressing the transcription factors SOX17 and ETV2, which significantly improves reprogramming efficiency and enhances endothelial characteristics such as eNOS expression. The study demonstrates that rECs exhibit increased expression of endothelial genes and can form large blood vessels in vivo, addressing previous limitations in reprogramming approaches. This advancement holds

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pushti.0415

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