Can I read Phasing the 30S ribosomal subunit structure on EtoBox?

Phasing the 30S ribosomal subunit structure by D. E. Brodersen; W. M. Clemons; A. P. Carter; B. T. Wimberly; V. Ramakrishnan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Phasing the 30S ribosomal subunit structure about?

The methods involved in determining the 850 kDa structure of the 30S ribosomal subunit from __Thermus thermophilus__ were in many ways identical to those that are generally used in standard protein crystallography. This paper reviews and analyses the methods that can be used in phasing such large structures and shows that the anomalous signal collected from heavy-atom compounds bound to the RNA is both necessary and sufficient for __ab initio__ structure determination at high resolution. In addition, measures to counter problems with non-isomorphism and radiation decay are described.

Who reads Phasing the 30S ribosomal subunit structure?

Author

D. E. Brodersen; W. M. Clemons; A. P. Carter; B. T. Wimberly; V. Ramakrishnan

Publisher

International Union of Crystallography; Blackwell Publishing Inc.; International Union of Crystallography (IUCr) (ISSN 0907-4449)

Published

2003

Language

EN

ISBN

9780907444909

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)