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Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models by David M Crizer; Sreenivasa C Ramaiahgari; Stephen S Ferguson; Julie R Rice; Paul E Dunlap; Nisha S Sipes; Scott S Auerbach; Bruce Alex Merrick; Michael J DeVito is a Economics, Econometrics and Finance article available to read on EtoBox.
What is Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models about?
## Abstract Interpretation of untargeted metabolomics data from both in vivo and physiologically relevant in vitro model systems continues to be a significant challenge for toxicology research. Potency-based modeling of toxicological responses has served as a pillar of interpretive context and translation of testing data. In this study, we leverage the resolving power of concentration-response modeling through benchmark concentration (BMC) analysis to interpret untargeted metabolomics data from differentiated cultures of HepaRG cells exposed to a panel of reference compounds and integrate data in a potency-aligned framework with matched transcriptomic data. For this work, we characterized biological responses to classical human liver injury compounds and comparator compounds, known to not cause liver injury in humans, at 10 exposure concentrations in spent culture media by untargeted liquid chromatography-mass spectrometry analysis. The analyte features observed (with limited metabolites identified) were analyzed using BMC modeling to derive compound-induced points of departure. The results revealed liver injury compounds produced concentration-related increases in metabolomic resp
Who reads Benchmark Concentrations for Untargeted Metabolomics Versus Transcriptomics for Liver Injury Compounds in In Vitro Liver Models?
It is typically read by researchers, students, and practitioners in Economics, Econometrics and Finance.
- Author
- David M Crizer; Sreenivasa C Ramaiahgari; Stephen S Ferguson; Julie R Rice; Paul E Dunlap; Nisha S Sipes; Scott S Auerbach; Bruce Alex Merrick; Michael J DeVito
- Publisher
- Oxford University Press (OUP)
- Published
- 2021
- Language
- EN
- Field
- Economics, Econometrics and Finance (Social Sciences)