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Can I read Viloxazine in the Management of CNS Disorders: A Historical Overview and Current Status on EtoBox?
Viloxazine in the Management of CNS Disorders: A Historical Overview and Current Status by Robert L. Findling; Shawn A. Candler; Azmi F. Nasser; Stefan Schwabe; Chungping Yu; Jennie Garcia-Olivares; Welton O’Neal; Jeffrey H. Newcorn is a Medicine article available to read on EtoBox.
What is Viloxazine in the Management of CNS Disorders: A Historical Overview and Current Status about?
Viloxazine has a long history of clinical use in Europe as an antidepressant, and has recently been repurposed into an extended-release form for the treatment of attention-deficit/hyperactivity disorder in the USA. An immediate-release formulation was approved for the treatment of depression in the UK in 1974, and was subsequently marketed there and in several European countries for 30 years with no major safety concerns. In contrast to first-generation antidepressants (e.g., tricyclic antidepressants, monoamine oxidase inhibitors), viloxazine was associated with a relatively low risk for cardiotoxicity. Gastrointestinal symptoms were the most commonly reported side effects. The therapeutic effects of viloxazine are thought to be primarily the result of its action as a norepinephrine reuptake inhibitor, although in vitro and preclinical in vivo animal data suggest that viloxazine may also impact the serotoninergic system. This review summarizes the evolving knowledge of viloxazine based on information from previously published preclinical and clinical investigations, and acquired unpublished historical study reports from both open-label and blinded controlled clinical trials. We re
Who reads Viloxazine in the Management of CNS Disorders: A Historical Overview and Current Status?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Robert L. Findling; Shawn A. Candler; Azmi F. Nasser; Stefan Schwabe; Chungping Yu; Jennie Garcia-Olivares; Welton O’Neal; Jeffrey H. Newcorn
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)