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NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4^+^ T Cells by Hainberger, Daniela; Stolz, Valentina; Zhu, Ci; Schuster, Michael; MÃ1⁄4ller, Lena; Hamminger, Patricia; Rica, Ramona; Waltenberger, Darina; Alteneder, Marlis; Krausgruber, Thomas; Hladik, Anastasiya; Knapp, Sylvia; Bock, Christoph; Trauner, Michael; Farrar, Michael A.; Ellmeier, Wilfried is a Immunology and Microbiology article available to read on EtoBox.

What is NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4^+^ T Cells about?

The differentiation of naïve CD4^+^ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific transcription factors with repressive chromatin-modifying enzymes in Th cells is yet unknown. Here we demonstrate an essential role for nuclear receptor corepressor 1 (NCOR1) in regulating naïve CD4^+^ T cell and Th1/Th17 effector transcriptomes. Moreover, NCOR1 binds to a conserved __cis__-regulatory element within the __Ifng__ locus and controls the extent of IFNγ expression in Th1 cells. Further, NCOR1 controls the survival of activated CD4^+^ T cells and Th1 cells __in vitro__, while Th17 cell survival was not affected in the absence of NCOR1. __In vivo__, effector functions were compromised since adoptive transfer of NCOR1-deficient CD4^+^ T cells resulted in attenuated colitis due to lower frequencies of IFNγ^+^ and IFNγ^+^IL-17A^+^ Th cells and overall reduced CD4^+^ T cell numbers. Collectively, our data demonstrate that the coregulator NCOR1 shapes transcriptional landscapes in CD4^+^ T cells and controls Th1/Th17 effector fun

Who reads NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4^+^ T Cells?

Author

Hainberger, Daniela; Stolz, Valentina; Zhu, Ci; Schuster, Michael; MÃ1⁄4ller, Lena; Hamminger, Patricia; Rica, Ramona; Waltenberger, Darina; Alteneder, Marlis; Krausgruber, Thomas; Hladik, Anastasiya; Knapp, Sylvia; Bock, Christoph; Trauner, Michael; Farrar, Michael A.; Ellmeier, Wilfried

Publisher

Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2010- (ISSN 1664-3224)

Published

2020

Language

EN

Field

Immunology and Microbiology (Life Sciences)