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Topical Glycolic Acid Enhances Photodamage by Ultraviolet Light by Kays Kaidbey; Betsy Sutherland; Paula Bennett; Wayne G. Wamer; Curtis Barton; Donna Dennis; Andrija Kornhauser is a Medicine article available to read on EtoBox.

What is Topical Glycolic Acid Enhances Photodamage by Ultraviolet Light about?

__Background:__ Alpha‐hydroxy acids (AHAs) are widely used as ingredients in cosmetics. Several studies suggest that AHAs can increase the sensitivity of skin to ultraviolet (UV) light. __Purpose:__ This study was performed in order to determine whether short‐term dermal treatment with glycolic acid, a representative AHA, can enhance the damaging effects of UV light. The duration of the effect of AHAs on the sensitivity of skin to UV light was also examined. __Methods:__ The backs of 29 Caucasian subjects were treated, once daily, 6 days per week with either 10% glycolic acid (pH 3.5) or placebo in a randomized double‐blinded study. At the end of 4 weeks, sites within each treated area were exposed to 1.5 MED of UV light, determined on previously untreated skin. Specimens were obtained for enumeration of sunburn cells (SBCs) in the first group of subjects (__n__ **=** 16), whereas cyclobutyl pyrimidine dimers (CPDs) in DNA were determined in the second group (__n__ **=** 13). The minimal erythema dose (MED) in each site was also determined in the first group of subjects. Sunburn cells and MEDs were re‐evaluated in the first group 1 week after discontinuing AHA applications. __Resul

Who reads Topical Glycolic Acid Enhances Photodamage by Ultraviolet Light?

Author

Kays Kaidbey; Betsy Sutherland; Paula Bennett; Wayne G. Wamer; Curtis Barton; Donna Dennis; Andrija Kornhauser

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0905-4383)

Published

2003

Language

EN

Field

Medicine (Health Sciences)