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Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization by Yongzheng Li; Jing Zhang; Chengze Wang; Zhiwei Jiang; Kaichen Lai; Ying Wang; Guoli Yang is a Engineering article available to read on EtoBox.
What is Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization about?
The application of mesenchymal stem cell (MSC)-based therapy is expected to make a significant contribution to the improvement of epithelial sealing around implants. However, there is currently no optimal MSC delivery biomaterial for clinical application in peri-implant epithelium (PIE) integration. In this study, we show that injectable photo-cross-linkable porous gelatin methacryloyl (GelMA)/silk fibroin glycidyl methacrylate (SilMA) hydrogels encapsulating gingival tissue-derived MSCs (GMSCs) are a simple and practical approach for re-epithelization applications. The hydrogels played a prominent role in supporting the proliferation, survival, and spread of GMSCs. Moreover, it was found that GMSCs-laden Porous GelMA/SilMA hydrogels could significantly upregulate the hemidesmosomes (HDs)-related genes and proteins expression and promote M2 polarization while inhibiting M1 polarization in vitro. Based on a rat model of early implant placement, application of the MSC-loaded hydrogels could enhance the protein expression of LAMA3 and BP180 (COL17A1) at the implant-PIE interface and reduce horseradish peroxidase (HRP) penetration between the implants and PIE. Noticeably, hydrogel-base
Who reads Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Yongzheng Li; Jing Zhang; Chengze Wang; Zhiwei Jiang; Kaichen Lai; Ying Wang; Guoli Yang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)