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Is a Nitrogen Atom an Important Pharmacophoric Element in Sigma Ligand Binding? by Seth Y Ablordeppey; James B Fischer; Richard A Glennon is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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AbstractÐA lingering question in s receptor ligand development is whether a nitrogen atom serves as an important pharmacophoric element in binding anity. To address this question, we have synthesized several phenylalkylpiperidines and phenylalkylpiperazines and demonstrated that removal of the N atom from a typical phenylalkylpiperidine led to little or no binding to s receptors. In addition, where two N atoms occur in a compound, such as with phenylalkylpiperazines, the N atom on the longer alkyl chain appears to be more important. Thus, based on this study, the N atom is an important pharmacophoric element in the binding of phenylalkylpiperidines and phenylalkylpiperazines to s receptors.

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Author

Seth Y Ablordeppey; James B Fischer; Richard A Glennon

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)