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Can I read A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors on EtoBox?
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors by James P. Guare; John S. Wai; Robert P. Gomez; Neville J. Anthony; Samson M. Jolly; Amanda R. Cortes; Joseph P. Vacca; Peter J. Felock; Kara A. Stillmock; William A. Schleif; Gregory Moyer; Lori J. Gabryelski; Lixia Jin; I-Wu Chen; Daria J. Hazuda; Steven D. Young is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors about?
A series of 5-amino derivatives of 8-hydroxy[1,6]-naphthyridine-7-carboxamide exhibiting sub-micromolar potency against replication of HIV-1 in cell culture was identified. One of these analogs, compound 12, displayed excellent pharmacokinetic properties when dosed orally in rats and in monkeys. This compound was demonstrated to be efficacious against replication of simian-human immunodeficiency virus (SHIV) 89.6P in infected rhesus macaques.
Who reads A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- James P. Guare; John S. Wai; Robert P. Gomez; Neville J. Anthony; Samson M. Jolly; Amanda R. Cortes; Joseph P. Vacca; Peter J. Felock; Kara A. Stillmock; William A. Schleif; Gregory Moyer; Lori J. Gabryelski; Lixia Jin; I-Wu Chen; Daria J. Hazuda; Steven D. Young
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)