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Congenital Abnormalities of 88 Children Born to Mothers Who Attempted Suicide with Phenobarbital During Pregnany: the Use of a Disaster Epidemiological Model for the Evaluation of Drug Teratogenicity by Gábor Timmermann; Nándor Ács; Ferenc Bánhidy; Andrew E. Czeizel is a Medicine article available to read on EtoBox.
What is Congenital Abnormalities of 88 Children Born to Mothers Who Attempted Suicide with Phenobarbital During Pregnany: the Use of a Disaster Epidemiological Model for the Evaluation of Drug Teratogenicity about?
## Abstract ## Objective To study the effect of large doses of phenobarbital used for a suicide attempt during pregnancy for fetuses to estimate the teratogenic potential of phenobarbital. ## Design and setting Comparative analysis of exposed children and their unexposed sibs born to pregnant patients who attempted suicide during pregnancy and admitted to the toxicological inpatient clinic, Budapest, 1960–1993. ## Study participants Of 1044 self‐poisoned pregnant women, 88 used phenobarbital for suicide attempt and delivered newborn babies. ## Main outcome measures Structural birth detects, i.e., congenital abnormalities (CAs). ## Results Doses ranged between 400 and 3000 mg of phenobarbital in 88 pregnant women who attempted suicide with this drug during pregnancy and later delivered live‐born babies. Twelve (13.6%) of 88 exposed children and eight (10.3%) of 78 sibs were affected with CAs (odds ratios (OR) with 95%CI: 1.4, 0.6–3.5). Of 88 exposed children, 34 were born to mothers who attempted suicide with phenobarbital between the 3rd and 12th postconceptional weeks, the critical period of most CAs; 3 had CAs (diaphragmatic defect, multiple CA, undescended testis), but only diap
Who reads Congenital Abnormalities of 88 Children Born to Mothers Who Attempted Suicide with Phenobarbital During Pregnany: the Use of a Disaster Epidemiological Model for the Evaluation of Drug Teratogenicity?
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- Author
- Gábor Timmermann; Nándor Ács; Ferenc Bánhidy; Andrew E. Czeizel
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-8569)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)