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Can I read Behavioral and Neural Effects of Intra-striatal Infusion of Anti-streptococcal Antibodies in Rats on EtoBox?
Behavioral and Neural Effects of Intra-striatal Infusion of Anti-streptococcal Antibodies in Rats by Dafna Lotan; Itai Benhar; Kathy Alvarez; Adita Mascaro-Blanco; Lior Brimberg; Dan Frenkel; Madeleine W. Cunningham; Daphna Joel is a Neuroscience article available to read on EtoBox.
What is Behavioral and Neural Effects of Intra-striatal Infusion of Anti-streptococcal Antibodies in Rats about?
Group A β-hemolytic streptococcal (GAS) infection is associated with a spectrum of neuropsychiatric disorders. The leading hypothesis regarding this association proposes that a GAS infection induces the production of auto-antibodies, which cross-react with neuronal determinants in the brain through the process of molecular mimicry. We have recently shown that exposure of rats to GAS antigen leads to the production of anti-neuronal antibodies concomitant with the development of behavioral alterations. The present study tested the causal role of the antibodies by assessing the behavior of naïve rats following passive transfer of purified antibodies from GAS-exposed rats. Immunoglobulin G (IgG) purified from the sera of GAS-exposed rats was infused directly into the striatum of naïve rats over a 21-day period. Their behavior in the induced-grooming, marble burying, food manipulation and beam walking assays was compared to that of naïve rats infused with IgG purified from adjuvant-exposed rats as well as of naïve rats. The pattern of in vivo antibody deposition in rat brain was evaluated using immunofluorescence and colocalization. Infusion of IgG from GAS-exposed rats to naïve rats le
Who reads Behavioral and Neural Effects of Intra-striatal Infusion of Anti-streptococcal Antibodies in Rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Dafna Lotan; Itai Benhar; Kathy Alvarez; Adita Mascaro-Blanco; Lior Brimberg; Dan Frenkel; Madeleine W. Cunningham; Daphna Joel
- Publisher
- Elsevier BV
- Published
- 2014
- Language
- EN
- Field
- Neuroscience (Life Sciences)