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Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels by Yijia Xu; Jianfang Sun; Wenwen Li; Suli Zhang; Liying Yang; Ying Teng; Kaikai Lv; Yanfeng Liu; Yang Su; Jinghai Zhang; Mingyi Zhao is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels about?
## Ethnopharmacology relevance: Pain often causes a series of abnormal changes in physiology and psychology, which can lead to disease and even death. drug therapy is the most basic and commonly used method for pain relief and management. interestingly, at present, hundreds of traditional chinese medicines have been reported to be used for pain relief, most of which are monomer preparations, which have been developed into new painkillers. corydalis yanhusuo is a representative of one of these medicines and is available for pain relief. ## Aim of the study: This study aims to determine the analgesic effect and the potential targets of the monomers derived from corydalis yanhusuo, and to explore any possible associated cardiac risk factors. ## Materials and methods: In this study, four monomers derived from corydalis yanhusuo (tetrahydropalmatine, corydaline, protopine, dehydrocorydaline) were tested in vivo, using the formalin-induced pain model to determine their analgesic properties. their potential targets were also determined using whole cell patch clamp recordings and myocardial enzyme assays. ## Results: The results showed that all monomers showed analgesic activity and inhibi
Who reads Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Yijia Xu; Jianfang Sun; Wenwen Li; Suli Zhang; Liying Yang; Ying Teng; Kaikai Lv; Yanfeng Liu; Yang Su; Jinghai Zhang; Mingyi Zhao
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)