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Disposition of Cannabidiol Metabolites in Serum and Urine from Healthy Individuals Treated with Pharmaceutical Preparations of Medical Cannabis by Pérez-Acevedo, Ana Pilar; BusardÃ2, Francesco Paolo; Pacifici, Roberta; Mannocchi, Giulio; Gottardi, Massimo; Poyatos, Lourdes; Papaseit, Esther; Pérez-Mañá, Clara; Martin, Soraya; Di Trana, Annagiulia; Pichini, Simona; Farré, Magí is a Medicine article available to read on EtoBox.

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The use of cannabis flowering tops with standardized amounts of active phytocannabinoids was recently authorized in several countries to treat several painful pathological conditions. The acute pharmacological effects and disposition of Δ-9-tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors and THC metabolites after oil and decoction administration have been already described. In this study, the disposition of CBD metabolites: 7-carboxy-cannabidiol (7-COOH-CBD), 7-hydroxycannabidiol (7-OH-CBD), 6-α-hydroxycannabidiol (6-α-OH-CBD), and 6-β-hydroxycannabidiol (6-β-OH-CBD) in the serum and urine of healthy volunteers was presented. Thirteen healthy volunteers were administered 100 mL of cannabis decoction in the first experimental session and, after 15 days of washout, 0.45 mL of oil. Serum and urine samples were collected at different time points, and the CBD metabolites were quantified by ultra-high-performance liquid chromatography–tandem mass spectrometry. The most abundant serum metabolite was 7-COOH-CBD, followed by 7-OH-CBD, 6-β-OH-CBD, and6-α-OH-CBD, after decoction and oil. Both 7-OH-CBD and the 6-α-OH-CBD showed similar pharmacokinetic properties followin

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Author

Pérez-Acevedo, Ana Pilar; BusardÃ2, Francesco Paolo; Pacifici, Roberta; Mannocchi, Giulio; Gottardi, Massimo; Poyatos, Lourdes; Papaseit, Esther; Pérez-Mañá, Clara; Martin, Soraya; Di Trana, Annagiulia; Pichini, Simona; Farré, Magí

Publisher

MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI Molecular Diversity Preservation International, 2004- (ISSN 1424-8247)

Published

2020

Language

EN

Field

Medicine (Life Sciences)