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Comparative expression analysis of the MAGED genes during embryogenesis and brain development by Mathieu Bertrand; Ivo Huijbers; Patrick Chomez; Olivier De Backer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The __MAGED__ gene subfamily contains three genes in mouse and four in human. The MAGED1, D2, and D3 proteins are highly conserved between mouse and human, whereas paralogues are less conserved between each other. This finding suggests that each MAGED protein exerts a distinct function. To get a better insight into their physiological roles, we have analyzed their expression patterns during embryogenesis and brain development. In the mouse, __Maged3__ expression is restricted to the central nervous system where it was mostly detected in postmitotic neurons. __Maged2__ is mainly expressed in tissues of mesodermal origin. The expression pattern of __Maged1__ roughly summarizes that of __Maged2__ and __Maged3__; however, contrary to that of __Maged3__, it includes the proliferative zones of the nervous system. We observed a discrepancy between Maged1 expression levels of RNA and protein, suggesting that its expression is regulated at a posttranscriptional level during the mouse development. Developmental Dynamics 230:325–334, 2004. © 2004 Wiley‐Liss, Inc.

Who reads Comparative expression analysis of the MAGED genes during embryogenesis and brain development?

Author

Mathieu Bertrand; Ivo Huijbers; Patrick Chomez; Olivier De Backer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1058-8388)

Published

2004

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)