About this Medicine article
Humoral Regulation of Iron Metabolism by Extracellular Vesicles Drives Antibacterial Response by Huijuan Kuang; Geng Dou; Linfeng Cheng; Xiangdong Wang; Haokun Xu; Xuemei Liu; Feng Ding; Xiaoshan Yang; Siying Liu; Lili Bao; Huan Liu; Yao Liu; Bei Li; Yan Jin; Shiyu Liu is a Medicine article available to read on EtoBox.
released by the host could bind and preserve iron-containing proteins and then recycle them back to macrophages, serving as circulating humoral 'iron catchers' to prevent bacteria from iron acquisition. In this study, we found that Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) induces endoplasmic reticulum stress (ERS) in host macrophages and activates inositol-requiring enzyme 1α (IRE1α) signaling, triggering lysosomal dysfunction and promoting EV release. EVs bearing receptors such as TfR bind iron-containing proteins, prevent bacteria from iron acquisition and recycle iron to tissue-resident macrophages, ultimately protecting against infection. Taken together, these findings reveal a previously unknown humoral regulatory mechanism of iron metabolism during bacterial infection, broadening the knowledge of iron metabolism in metabolism. First, several studies have found that the number of circulating EVs is highly increased in response to bacterial infection 7,8 . In addition, circulating EVs are captured mainly by liver or spleen macrophages 9 , which is consistent with the route of iron recycling by the host during bacterial infection. Moreover, EVs ca
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- Author
- Huijuan Kuang; Geng Dou; Linfeng Cheng; Xiangdong Wang; Haokun Xu; Xuemei Liu; Feng Ding; Xiaoshan Yang; Siying Liu; Lili Bao; Huan Liu; Yao Liu; Bei Li; Yan Jin; Shiyu Liu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Life Sciences)