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Zinc Supplementation Increases Bone Alkaline Phosphatase in Healthy Men by Anne Peretz; Théodore Papadopoulos; Dominique Willems; Anouk Hotimsky; Nicole Michiels; Vania Siderova; Pierre Bergmann; Jean Neve is a Environmental Science article available to read on EtoBox.

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Zinc takes part in the metaboUsm of bone as a constituent of the matrix and as an activator of several metal[o-enzymes. Animal in vitro and in vivo studies strongly suggest that zinc supplementation could stimulate bone formation and inhibit bone resorption but data in humans remain rare. The biological effects of 50 mg zinc given orally as gLuconate in 20 healthy male volunteers were investigated in a 12 weeks doubte-b[ind p[acebo-contro[ted randomized trial To investigate bone turnover, total alkaline phosphatases activity (ALP), bone specific alkaline phosphatase activity (BAP-E) and BAP mass (BAP-M) concentration were measured as parameters of bone formation while urine calcium and C-terminal collagen peptide were determined as parameters of bone resorption. Samples were obtained in fasting subjects at baseline and after 6 and 12 weeks. In zinc treated subjects, a significant increase was observed at Least after 12 weeks in total ALP (p < 0.01), BAP-M (p < 0.05) and BAP-E (p < 0.02). These parameters did not significantly change in the placebo group. Urine zinc/creatinine ratio significantly increased after 6 (p < 0.03) and 12 weeks (p < 0.04) in the zinctreated group and was s

Who reads Zinc Supplementation Increases Bone Alkaline Phosphatase in Healthy Men?

Author

Anne Peretz; Théodore Papadopoulos; Dominique Willems; Anouk Hotimsky; Nicole Michiels; Vania Siderova; Pierre Bergmann; Jean Neve

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0946-672X)

Published

2001

Language

EN

Field

Environmental Science (Physical Sciences)