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Biocompatibility of Reduced Graphene Oxide Nanoscaffolds Following Acute Spinal Cord Injury in Rats by Andrew Jea; AliH Palejwala; JaredS Fridley; JavierA Mata; ErrolL. G. Samuel; ThomasG Luerssen; Laszlo Perlaky; ThomasA Kent; JamesM Tour is a Medicine article available to read on EtoBox.
What is Biocompatibility of Reduced Graphene Oxide Nanoscaffolds Following Acute Spinal Cord Injury in Rats about?
## Background: Graphene has unique electrical, physical, and chemical properties that may have great potential as a bioscaffold for neuronal regeneration after spinal cord injury. These nanoscaffolds have previously been shown to be biocompatible __in vitro__; in the present study, we wished to evaluate its biocompatibility in an __in vivo__ spinal cord injury model. ## Methods: Graphene nanoscaffolds were prepared by the mild chemical reduction of graphene oxide. Twenty Wistar rats (19 male and 1 female) underwent hemispinal cord transection at approximately the T2 level. To bridge the lesion, graphene nanoscaffolds with a hydrogel were implanted immediately after spinal cord transection. Control animals were treated with hydrogel matrix alone. Histologic evaluation was performed 3 months after the spinal cord transection to assess __in vivo__ biocompatibility of graphene and to measure the ingrowth of tissue elements adjacent to the graphene nanoscaffold. ## Results: The graphene nanoscaffolds adhered well to the spinal cord tissue. There was no area of pseudocyst around the scaffolds suggestive of cytotoxicity. Instead, histological evaluation showed an ingrowth of connective ti
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It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Andrew Jea; AliH Palejwala; JaredS Fridley; JavierA Mata; ErrolL. G. Samuel; ThomasG Luerssen; Laszlo Perlaky; ThomasA Kent; JamesM Tour
- Publisher
- Scientific Scholar
- Published
- 2016
- Language
- EN
- Field
- Medicine (Health Sciences)