Opening book details…
Can I read Bacterial adhesion on hybrid cationic nanoparticle–polymer brush surfaces: Ionic strength tunes capture from monovalent to multivalent binding on EtoBox?
Bacterial adhesion on hybrid cationic nanoparticle–polymer brush surfaces: Ionic strength tunes capture from monovalent to multivalent binding by Bing Fang; Saugata Gon; Myoung Park; Kushi-Nidhi Kumar; Vincent M. Rotello; Klaus Nusslein; Maria M. Santore is a Materials Science article available to read on EtoBox.
What is Bacterial adhesion on hybrid cationic nanoparticle–polymer brush surfaces: Ionic strength tunes capture from monovalent to multivalent binding about?
This paper describes the creation of hybrid surfaces containing cationic nanoparticles and biocompatible PEG (polyethylene glycol) brushes that manipulate bacterial adhesion for potential diagnostic and implant applications. Here, ∼10 nm cationically functionalized gold nanoparticles are immobilized randomly on negative silica surfaces at tightly controlled surface loadings, and the remaining areas are functionalized with a hydrated PEG brush, using a graft copolymer of poly-l-lysine and PEG (PLL-PEG), containing 2000 molecular weight PEG chains and roughly 30% functionalization of the PLL. The cationic nanoparticles attract the negative surfaces of suspended Staphylococcus aureus bacteria while the PEG brush exerts a steric repulsion. With the nanoparticle and PEG brush heights on the same lengthscale, variations in ionic strength are demonstrated to profoundly influence the capture of S. aureus on these surfaces. For bacteria captured from gentle flow, a crossover from multivalent to univalent binding is demonstrated as the Debye length is increased from 1 to 4 nm. In the univalent regime, 1 um diameter spherical bacteria are captured and held by single nanoparticles. In the mult
Who reads Bacterial adhesion on hybrid cationic nanoparticle–polymer brush surfaces: Ionic strength tunes capture from monovalent to multivalent binding?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Bing Fang; Saugata Gon; Myoung Park; Kushi-Nidhi Kumar; Vincent M. Rotello; Klaus Nusslein; Maria M. Santore
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0927-7765)
- Published
- 2011
- Language
- EN
- Field
- Materials Science (Physical Sciences)