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Cost Effectiveness of Screening Strategies for Early Identification of HIV and HCV Infection in Injection Drug Users by Cipriano, Lauren E.; Zaric, Gregory S.; Holodniy, Mark; Bendavid, Eran; Owens, Douglas K.; Brandeau, Margaret L.; Blackard, Jason is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Cost Effectiveness of Screening Strategies for Early Identification of HIV and HCV Infection in Injection Drug Users about?
## Objective To estimate the cost, effectiveness, and cost effectiveness of HIV and HCV screening of injection drug users (IDUs) in opioid replacement therapy (ORT). ## Design Dynamic compartmental model of HIV and HCV in a population of IDUs and non-IDUs for a representative U.S. urban center with 2.5 million adults (age 15–59). ## Methods We considered strategies of screening individuals in ORT for HIV, HCV, or both infections by antibody or antibody and viral RNA testing. We evaluated one-time and repeat screening at intervals from annually to once every 3 months. We calculated the number of HIV and HCV infections, quality-adjusted life years (QALYs), costs, and incremental cost-effectiveness ratios (ICERs). ## Results Adding HIV and HCV viral RNA testing to antibody testing averts 14.8–30.3 HIV and 3.7–7.7 HCV infections in a screened population of 26,100 IDUs entering ORT over 20 years, depending on screening frequency. Screening for HIV antibodies every 6 months costs $30,700/QALY gained. Screening for HIV antibodies and viral RNA every 6 months has an ICER of $65,900/QALY gained. Strategies including HCV testing have ICERs exceeding $100,000/QALY gained unless awareness of H
Who reads Cost Effectiveness of Screening Strategies for Early Identification of HIV and HCV Infection in Injection Drug Users?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Cipriano, Lauren E.; Zaric, Gregory S.; Holodniy, Mark; Bendavid, Eran; Owens, Douglas K.; Brandeau, Margaret L.; Blackard, Jason
- Publisher
- Public Library of Science; San Francisco CA: Public Library of Science; Publons; ScienceOpen; Public Library of Science (PLoS) (ISSN 1932-6203)
- Published
- 2012
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)