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Can I read Pharmacokinetics of native Escherichia coli asparaginase (Asparaginase medac) and hypersensitivity reactions in ALL‐BFM 95 reinduction treatment on EtoBox?
Pharmacokinetics of native Escherichia coli asparaginase (Asparaginase medac) and hypersensitivity reactions in ALL‐BFM 95 reinduction treatment by Hans‐Joachim Müller; Rita Beier; Lutz Löning; Renate Blütters‐Sawatzki; Wolfgang Dörffel; Eberhard Maass; Stefan Müller‐Weihrich; Hans‐Georg Scheel‐Walter; Franziska Scherer; Karsten Stahnke; Martin Schrappe; Alexander Horn; Karen Lümkemann; Joachim Boos is a Medicine article available to read on EtoBox.
What is Pharmacokinetics of native Escherichia coli asparaginase (Asparaginase medac) and hypersensitivity reactions in ALL‐BFM 95 reinduction treatment about?
Repeated asparaginase treatment has been associated with hypersensitivity reactions against the bacterial macromolecule in a considerable number of patients. Immunological reactions may range from anaphylaxis without impairment of serum asparaginase activity to a very fast decline in enzyme activity without any clinical symptoms. Previous investigations on a limited number of patients have shown high interindividual variability of asparaginase activity time courses and hypersensitivity reactions in about 30% of patients during reinduction treatment. Therefore, monitoring of reinduction treatment was performed prospectively in 76 children with newly diagnosed acute lymphoblastic leukaemia (ALL). According to the ALL‐Berlin–Frankfurt–Münster (BFM) 95 protocol, 10 000 U/m^2^ body surface area of native __Escherichia coli__ asparaginase (Asparaginase medac) was given on d 8, 11, 15 and 18. In 45/76 children, trough and peak activities were determined with every dose, and also on d 4 and d 11 after the last administration. Data on asparaginase activity were not available from the remaining 31 patients, but information with regard to hypersensitivity reactions only was given. Eighteen ou
Who reads Pharmacokinetics of native Escherichia coli asparaginase (Asparaginase medac) and hypersensitivity reactions in ALL‐BFM 95 reinduction treatment?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hans‐Joachim Müller; Rita Beier; Lutz Löning; Renate Blütters‐Sawatzki; Wolfgang Dörffel; Eberhard Maass; Stefan Müller‐Weihrich; Hans‐Georg Scheel‐Walter; Franziska Scherer; Karsten Stahnke; Martin Schrappe; Alexander Horn; Karen Lümkemann; Joachim Boos
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)