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Synthesis and Chiroptical Properties of Heterodetic Cyclic Hexapeptides Related to Oxytocin Ring Moiety by Frič, Ivo; Leonteva, Lyudmila I.; Maloň, Petr; Jošt, Karel; Bláha, Karel is a Chemistry article available to read on EtoBox.

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Cyclic disulfides of cysteinyl-tetraglycyl-cysteine (Ia), cysteinyl-tyrosyl-triglycyl-cysteine (Ib) and cysteinyl-tyrosyl-isoleucyl-diglycyl-cysteine (Ic) were synthesized by classical methods of peptide synthesis. The actions of solvent and of side chains in the positions 2 and 3 on the conformational arrangement of the peptide backbone and the disulfide group were investigated by means of CD spectroscopy. Some mechanisms which co-operate in stabilizing the oxytocin conformation were identified. Hence, it may be deduced, that the amino acid sequence in the positions 1-3 determines the spatial arrangement characteristic for oxytocin, at least in a protonating medium.

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Author

Frič, Ivo; Leonteva, Lyudmila I.; Maloň, Petr; Jošt, Karel; Bláha, Karel

Publisher

UOCHB; Institute of Organic Chemistry & Biochemistry, Academy of Sciences of the Czech Republic; Akademie Ved Ceske Republiky; Institute of Organic Chemistry & Biochemistry (ISSN 0010-0765)

Published

1980

Language

EN

Field

Chemistry (Physical Sciences)