About this Neuroscience article
Tellurium-induced neuropathy: A model for reversible reductions in myelin protein gene expression by Dr. A. D. Toews; S. Y. Lee; B. Popko; P. Morell is a Neuroscience article available to read on EtoBox.
Inclusion of 1.1 % tellurium in the diet of developing rats causes a highly synchronous primary demyelination of peripheral nerves, which is followed closely by a period of rapid remyelination. The demyelination is related to the inhibition of squalene epoxidase activity, which results in a block in cholesterol synthesis and accumulation of squalene. We now report that the demyelination resulting from this limiting of the supply of an intrinsic component of myelin (cholesterol) leads to repression of the expression of mRNA for myelin-specific proteins. Tellurium exposure resulted in an increase in total RNA (largely rRTVA) in sciatic nerve, which could not be accounted for by cellular proliferation; these increased levels of rRNA may be a reactive response of Schwann cells to toxic insult and may relate to the higher levels of protein synthesis required during remyelination. In contrast, steadystate levels of mRNA, determined by Northern blot analysis, for Po and myelin basic protein were markedly decreased (levels after 5 days of tellurium exposure were only 10-15% of control levels as a fraction of total RNA and 25-35% of control levels when the increased levels of total RNA were
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Dr. A. D. Toews; S. Y. Lee; B. Popko; P. Morell
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 1990
- Language
- EN
- Field
- Neuroscience (Life Sciences)