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This document presents a spatial multiscale model for simulating calcium puff dynamics in cells, focusing on the release of Ca2+ ions from inositol-4,5-triphosphate receptor (IP3 R) channels. The model combines Brownian motion of ions with a stochastic channel gating model to analyze calcium puff statistics and identify conditions for puff generation. The findings enhance the understanding of intracellular calcium signaling, which is crucial for various cellular functions and related diseases.

Author

Advaith Prakash

Language

EN