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Noradrenergic neurons release both noradrenaline and neuropeptide Y from a single pool: The large dense cored vesicles by W.P. De Potter; P. Partoens; A. Schoups; I. Llona; E.P. Coen is a Neuroscience article available to read on EtoBox.

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In peripheral adrenergic nerve endings, noradrenaline is stored in two different types of vesicles, the large and the small dense cored vesicles. A systematic study was undertaken to examine the release of noradrenaline and neuropeptide Y from dog spleen and rat vas deferens under various conditions of stimulation, particularly those which previously have demonstrated a differential regulation of exocytosis of the different types of storage vesicles. Here we present evidence that noradrenaline is released by exocytosis exclusively from the large dense cored vesicles, in which it is stored together with neuropeptide Y. Upon a single stimulation (at frequencies varying from 2-20 Hz), the release of noradrenaline and neuropeptide Y from the dog splenic nerve increased with the frequency of stimulation, but the ratio of noradrenaline to neuropeptide Y remained constant. After repeated stimulation of the splenic nerve, both substances' overflow decreased gradually and in parallel to values of 12.5% and 11.1% of the first stimulation for noradrenaline and neuropeptide Y, respectively. Similarly, repeated stimulation of the rat vas deferens (of which only 2-10% is large dense cored vesicl

Who reads Noradrenergic neurons release both noradrenaline and neuropeptide Y from a single pool: The large dense cored vesicles?

Author

W.P. De Potter; P. Partoens; A. Schoups; I. Llona; E.P. Coen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

1997

Language

EN

Field

Neuroscience (Life Sciences)