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This study introduces a hybrid computational fluid dynamics (CFD) model that integrates hydrodynamics, kinetics, and control systems for mammalian bioprocesses in single-use bioreactors across three scales (250 mL, 1000 L, and 2000 L). The model optimizes feed delivery and control systems, revealing that glutamine concentration significantly affects cell growth, while glucose concentration has minimal impact. The approach demonstrates a time-efficient simulation of bioprocesses, achieving results in one-ten
- Author
- Yash Banabakode
- Language
- EN