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Codon Bias Affects Protein Folding by Jenny Wang is a document available to read on EtoBox.
Synonymous codons direct cotranslational folding toward different protein conformations. The study demonstrates that synonymous codon usage manipulates translation kinetics and leads to changed cotranslational folding trajectories and ultimately different protein conformations. Specifically, the study found that a gamma-B crystallin variant with optimized codon usage (H variant) developed protease resistance faster and attained folding faster than an unoptimized variant (U variant) due to differences in tra
- Author
- Jenny Wang
- Language
- EN