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Low-frequency Subthalamic Stimulation in Parkinson's Disease: Long-term Outcome and Predictors by Maurizio Zibetti; Elena Moro; Vibhor Krishna; Francesco Sammartino; Marina Picillo; Renato P. Munhoz; Andres M. Lozano; Alfonso Fasano is a Neuroscience article available to read on EtoBox.

What is Low-frequency Subthalamic Stimulation in Parkinson's Disease: Long-term Outcome and Predictors about?

## Background: Parkinson's disease patients undergoing subthalamic nucleus deep brain stimulation (stn dbs) at standard frequency (>100 hz) often develop gait impairment, postural instability and speech difficulties. low frequency stimulation (<100 hz, lfs) can improve such axial symptoms, but there are concerns that improvement may be transient. ## Objective: To identify long-term outcome and predictors of low-frequency subthalamic stimulation in parkinson's disease. ## Methods: Through a chart review we identified 85 out of 324 stn dbs patients who received a trial of lfs and describe their characteristics and outcome predictors. ## Results: Patients were switched to lfs (<100 hz) 3.8 ± 3.3 years after surgery. most patients (64%) attained a subjective improvement of gait, speech or balance for 2.0 ± 1.9 years. motor scores improved within the first year after the stimulation change and showed a slower progression over time when compared to patients switched back to high frequency stimulation. updrs iii axial score on medication before surgery and the y-axis coordinate of the active contact were independent predictors of lfs retention. ## Conclusions: This report provides evidenc

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Author

Maurizio Zibetti; Elena Moro; Vibhor Krishna; Francesco Sammartino; Marina Picillo; Renato P. Munhoz; Andres M. Lozano; Alfonso Fasano

Publisher

Elsevier ; Elsevier BV (ISSN 1935-861X)

Published

2016

Language

EN

Field

Neuroscience (Life Sciences)