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Effects of Grape Seed Proanthocyanidins Extract on Mandibles in Developing Rats by Y Kamitani; K Maki; I Tofani; Y Nishikawa; K Tsukamoto; M Kimura is a Dentistry article available to read on EtoBox.

What is Effects of Grape Seed Proanthocyanidins Extract on Mandibles in Developing Rats about?

**Objective:** Grape seed proanthocyanidins extract (GSPE), a flavonoid, has a beneficial effect on physical health, which may include the health of bone. The purpose of the present study was to investigate the effects of GSPE on mandibular bone by examining trabecular and cortical bone density, mineral content, and non‐invasive bone strength in low‐calcium diet rats. **Materials and methods:** Wistar male rats at 5 weeks old (__n__ = 40) were divided into control (A), low‐calcium diet (B), low‐calcium diet plus standard diet (C), and low‐calcium diet plus standard diet with supplementary GSPE (D) groups. Following 3 weeks of a calcium‐restricted diet, group D rats were given 3 mg of GSPE as supplement in 100 g of a standard diet for the next 3 weeks. Following the 6‐week experimental period, mandibular bones were examined using peripheral quantitative computed tomography (pQCT). **Results:** There were no significant differences in body weight or trabecular bone area among the four groups. Trabecular bone density, and trabecular bone mineral content, cortical bone density, cortical bone cross‐sectional area, and cortical bone mineral content were significantly higher in group D th

Who reads Effects of Grape Seed Proanthocyanidins Extract on Mandibles in Developing Rats?

Author

Y Kamitani; K Maki; I Tofani; Y Nishikawa; K Tsukamoto; M Kimura

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley (ISSN 1354-523X)

Published

2003

Language

EN

Field

Dentistry (Health Sciences)