About this Pharmacology, Toxicology and Pharmaceutics article

Excipient Effects on Gastrointestinal Transit and Drug Absorption in Beagle Dogs by Julia D.R. Schulze; Erin E. Peters; Ann W. Vickers; J. Scott Staton; Mark D. Coffin; Gary E. Parsons; Abdul W. Basit is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

Previous work has shown that polyethylene glycol 400 (PEG 400) has an accelerating effect on gastrointestinal transit and a modulating influence on drug absorption in humans. The aim of this study was to assess the impact of various excipients, PEG 400, propylene glycol, d-alpha-tocopheryl-polyethylene glycol-1000 succinate (TPGS) and Labrasol on gastrointestinal transit and drug absorption in four beagle dogs using scintigraphy. Each dog received, on five separate occasions, water (control) or a dose of excipient equivalent to 1 g PEG 400, 2 g propylene glycol, 1 g TPGS or 2 g Labrasol dissolved in water and administered in the form of two capsules. The model drugs ampicillin (200mg) and antipyrine (100mg) were co-administered in the capsules. The capsule solutions were radiolabelled with technetium-99m to follow their transit using a dual-headed gamma camera, and blood samples were collected to determine drug pharmacokinetics. On a separate occasion, the drugs were dissolved in saline and given intravenously. The capsules rapidly disintegrated in the stomach liberating their liquid contents. The mean small intestinal transit times for the different treatments (control, PEG 400, p

Author

Julia D.R. Schulze; Erin E. Peters; Ann W. Vickers; J. Scott Staton; Mark D. Coffin; Gary E. Parsons; Abdul W. Basit

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2005

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)