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Repositioning of Fungal-based Peptides as Modulators of Angiotensin-converting Enzyme-related Carboxypeptidase, SARS-coronavirus HR2 Domain, and Coronavirus Disease 2019 Main Protease by Babatunde Joseph Oso; Clement Olusola Ogidi is a Medicine article available to read on EtoBox.
What is Repositioning of Fungal-based Peptides as Modulators of Angiotensin-converting Enzyme-related Carboxypeptidase, SARS-coronavirus HR2 Domain, and Coronavirus Disease 2019 Main Protease about?
## Abstract ## Background and Objectives Angiotensin-converting enzyme-related carboxypeptidase, SARS-Coronavirus HR2 Domain, and COVID-19 main protease are essential for the cellular entry and replication of coronavirus in the host. This study investigated the putative inhibitory action of peptides form medicinal mushrooms, namely __Pseudoplectania nigrella__, __Russula paludosa__, and __Clitocybe sinopica__, towards selected proteins through computational studies. ## Materials and Methods The respective physicochemical properties of selected peptides were predicted using ProtParam tool, while the binding modes and binding free energy of selected peptides toward proteins were computed through HawkDock server. The structural flexibility and stability of docked protein–peptide complexes were assessed through iMODS server. ## Results The peptides showed an optimum binding afinity with the molecular targets; plectasin from __P. nigrella__ showed the highest binding free energy compared to peptides from __R. paludosa__ and __C. sinopica__. Besides, molecular dynamic simulations showed all fungal-based peptides could influence the flexibility and stability of selected proteins. ## Concl
Who reads Repositioning of Fungal-based Peptides as Modulators of Angiotensin-converting Enzyme-related Carboxypeptidase, SARS-coronavirus HR2 Domain, and Coronavirus Disease 2019 Main Protease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Babatunde Joseph Oso; Clement Olusola Ogidi
- Publisher
- Walter de Gruyter GmbH
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)
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