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What is IL-18 about?

This document reviews the roles of interleukin-18 (IL-18) in activating basophils and mast cells to induce innate allergic responses. It discusses how IL-18, along with IL-3 or Toll-like receptor ligands, can stimulate these cells to produce Th2 cytokines and mediators involved in allergic inflammation, even without antigen-specific IgE crosslinking. This represents an IgE-independent "innate allergic response" that may help protect against helminth infections. In contrast, the conventional IgE-dependent ac

Author

Anni Muharomah

Language

EN