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Methods for the Early Detection of Drug-induced Pancreatitis: a Systematic Review of the Literature by Wolfe, Dianna; Kanji, Salmaan; Yazdi, Fatemeh; Skidmore, Becky; Moher, David; Hutton, Brian is a Medicine article available to read on EtoBox.

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## Objectives We systematically reviewed the literature to identify evidence-informed recommendations regarding the detection of drug-induced pancreatitis (DIP) and, secondarily, to describe clinical processes for the diagnosis of DIP. ## Design Systematic review. ## Data sources Ovid MEDLINE, including Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Embase Classic+Embase, the Cochrane Library. ## Eligibility criteria We included clinical practice guidelines, systematic reviews, narrative reviews and observational studies with a focus of establishing incidence, prevalence or diagnostic approaches for DIP. Clinical trials that diagnosed DIP as an outcome were also included. ## Data extraction and synthesis Two reviewers screened citations and performed data extraction. A narrative synthesis of the evidence was prepared. ## Results Fifty-nine studies were included. Early published evidence suggested serial pancreatic ultrasound could detect subclinical pancreatitis; however, subsequent studies demonstrated no utility of serial ultrasound or serial monitoring of pancreatic enzymes in the early detection of DIP. Two small studies conducted in patients with a high baselin

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Author

Wolfe, Dianna; Kanji, Salmaan; Yazdi, Fatemeh; Skidmore, Becky; Moher, David; Hutton, Brian

Publisher

BMJ; BMJ Publishing Group; London: BMJ Publishing (ISSN 2044-6055)

Published

2019

Language

EN

Field

Medicine (Health Sciences)