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An Alternative Spirometric Measurement. Area under the Expiratory Flow–Volume Curve by Octavian C. Ioachimescu; James K. Stoller is a Medicine article available to read on EtoBox.

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**Rationale:** Interpretation of spirometry is influenced by inherent limitations and by the normal or predicted reference values used. For example, traditional spirometric parameters such as “distal” airflows do not provide sufficient differentiating capacity, especially for mixed patterns or small airway disease. **Objectives:** We assessed the utility of an alternative spirometric parameter (area under the expiratory flow–volume curve [AEX]) in differentiating between normal, obstruction, restriction, and mixed patterns, as well as in severity stratification of traditional functional impairments. **Methods:** We analyzed 15,308 spirometry tests in subjects who had same-day lung volume assessments in a pulmonary function laboratory. Using Global Lung Initiative predicted values and standard criteria for pulmonary function impairment, we assessed the diagnostic performance of AEX in best-split partition and artificial neural network models. **Results:** The average square root AEX values were 3.32, 1.81, 2.30, and 1.64 L⋅s^−0.5^ in normal, obstruction, restriction, and mixed patterns, respectively. As such, in combination with traditional spirometric measurements, the square root

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Author

Octavian C. Ioachimescu; James K. Stoller

Publisher

American Thoracic Society (ISSN 2325-6621)

Published

2020

Language

EN

Field

Medicine (Health Sciences)