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Synthesis, Structure Elucidation and H^+^/K^+^‐ATPase Inhibitory Activity of Bisabolangelone Reduction Derivatives by Nianyu Huang; Lei Chen; Zhaojiang Liao; Hubiao Fang; Junzhi Wang; Kun Zou is a Chemistry article available to read on EtoBox.

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## Abstract Nine bisabolangelone reduction derivatives were synthesized and separated as potential anti‐ulcer agent. Their structures were characterized by 2D NMR, IR, ESI‐MS, elemental analysis and single‐crystal X‐ray diffraction analysis. Preliminarily H^+^/K^+^‐ATPase activity evaluation indicated that all the target compounds had a certain inhibitory effect, and compounds **II** and **IV** exhibited the better inhibitory activity against H^+^/K^+^‐ATPase than bisabolangelone and the commercial omeprazole with the IC~50~ of 23.21 and 65.32 μmol/L, respectively. The initial structure‐activity analysis suggested that the presence of carbonyl group in six‐membered ring and double bond in side‐chain seemed to be necessary to the activity.

Who reads Synthesis, Structure Elucidation and H^+^/K^+^‐ATPase Inhibitory Activity of Bisabolangelone Reduction Derivatives?

Author

Nianyu Huang; Lei Chen; Zhaojiang Liao; Hubiao Fang; Junzhi Wang; Kun Zou

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Science Press; Wiley (ISSN 0256-7660)

Published

2011

Language

EN

Field

Chemistry (Physical Sciences)