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Detection of Cytotoxic Non-HL-A Antisera by M.E. Dorf; S.Y. Eguro; G. Cabrera; E.J. Yunis; J. Swanson; D.B. Amos is a Medicine article available to read on EtoBox.

What is Detection of Cytotoxic Non-HL-A Antisera about?

A lymphocytotoxic serum with unknown non-HL-A specificity was shown to detect Lea antigen on the lymphocytes of Le(a + ) individuals. Hemagglutinating anti-Lea was present as well. The reactions of both antibodies were in complete agreement when tested against the red cells and lymphocytes of random donors and in family analyses. Lymphocytotoxic antibodies of Lea specificity were observed in five of six samples of anti-Lea sera, but three anti-Leb failed to demonstrate cytotoxic activity. The optimal thermal activity for anti-Lea cytotoxins was 22 °C as compared to two examples of cold cytotoxins reactive at 15°C. The possible presence of cytotoxic Lewis antibodies inHL-A typing sera should be considered, particularly when a 22 °C phase is empoyed in the technique.

Who reads Detection of Cytotoxic Non-HL-A Antisera?

Author

M.E. Dorf; S.Y. Eguro; G. Cabrera; E.J. Yunis; J. Swanson; D.B. Amos

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0042-9007)

Published

1972

Language

EN

Field

Medicine (Health Sciences)