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Strategy for the isolation and identification of coumarins with calcium antagonistic properties from the roots of Angelica archangelica by P. Härmälä; H. Vuorela; R. Hiltunen; Sz. Nyiredy; O. Sticher; K. Törnquist; S. Kaltia is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Fifteen coumarins, 2′‐angeloyl‐3′‐isovaleryl vaginate (4), archangelicin (3), oxypeucedanin hydrate (8), bergapten (5), byakangelicin angelate (15), imperatorin (11), isoimperatorin (6), isopimpinellin (13), 8‐[2‐(3‐methylbutroxy)‐3‐hydroxy‐3‐methylbutoxy]psoralen (12), osthol (1), ostruthol (9), oxypeucedanin (7), phellopterin (14), psoralen (2) and xanthotoxin (10), have been isolated from a chloroform extract of the roots of __Angelica archangelica__ L. subsp. __archangelica__ (Apiaceae). 2, 4, 12, and 15 are reported for the first time from A. __archangelica__ L. The isolation was carried out using medium pressure liquid chromatography (MPLC) using the normal phase mode and then subsequently using a combination of the reversed and normal phase techniques. The eluents were optimized by thin layer chromatography and high performance liquid chromatography preassays according to the “PRISMA” system, and then transferred without modification of the solvent selectivity to preparative MPLC separations. The structures of the compounds were elucidated by a combination of spectroscopic methods. The isolation was carried out from a chloroform extract which in earlier tests had

Who reads Strategy for the isolation and identification of coumarins with calcium antagonistic properties from the roots of Angelica archangelica?

Author

P. Härmälä; H. Vuorela; R. Hiltunen; Sz. Nyiredy; O. Sticher; K. Törnquist; S. Kaltia

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0958-0344)

Published

1992

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)