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Blood Metabolomics in Infants Enrolled in a Dose Escalation Pilot Trial of Budesonide in Surfactant by Philip L. Ballard; Dara Torgerson; Rajan Wadhawan; Mark L. Hudak; Joern-Hendrik Weitkamp; Julia Harris; Jeanette Asselin; Cheryl Chapin; Roberta A. Ballard; Cindy T. McEvoy is a Medicine article available to read on EtoBox.
What is Blood Metabolomics in Infants Enrolled in a Dose Escalation Pilot Trial of Budesonide in Surfactant about?
## Background: The pathogenesis of bpd includes inflammation and oxidative stress in the immature lung. corticosteroids improve respiratory status and outcome, but the optimal treatment regimen for benefit with low systemic effects is uncertain. ## Methods: In a pilot dose escalation trial, we administered ≤5 daily doses of budesonide in surfactant to 24 intubated premature infants (steroid and surfactant in elgans (sassie)). untargeted metabolomics was performed on dried blood spots using uplc-ms/ms. tracheal aspirate il-8 concentration was determined as a measure of lung inflammation. ## Results: Metabolomics data for 829 biochemicals were obtained on 121 blood samples over 96 h from 23 infants receiving 0.025, 0.05, or 0.1 mg budesonide/kg. ninety metabolites were increased or decreased in a time- and dose-dependent manner at q ≤ 0.1 with overrepresentation in lipid and amino acid super pathways. different dose response patterns occurred, with negative regulation associated with highest sensitivity to budesonide. baseline levels of 22 regulated biochemicals correlated with lung inflammation (il-8), with highest significance for sphingosine and thiamin. ## Conclusions: Numerous m
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- Author
- Philip L. Ballard; Dara Torgerson; Rajan Wadhawan; Mark L. Hudak; Joern-Hendrik Weitkamp; Julia Harris; Jeanette Asselin; Cheryl Chapin; Roberta A. Ballard; Cindy T. McEvoy
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)