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Evaluation of the ‘Ring Sign’ and the ‘Core Sign’ as a Magnetic Resonance Imaging Marker of Disease Activity and Progression in Clinically Isolated Syndrome and Early Multiple Sclerosis by Nelly Blindenbacher; Eveline Brunner; Susanna Asseyer; Michael Scheel; Nadja Siebert; Ludwig Rasche; Judith Bellmann-Strobl; Alexander Brandt; Klemens Ruprecht; Dominik Meier; Jens Wuerfel; Friedemann Paul; Tim Sinnecker is a Medicine article available to read on EtoBox.

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## Background Brain lesions with a hypointense ring or core were described in multiple sclerosis on susceptibility weighted imaging. ## Objective The purpose of this study was to study the evolution and prognostic relevance of susceptibility weighted imaging hypointense lesions in clinically isolated syndrome and early multiple sclerosis. ## Methods Sixty-six early multiple sclerosis and clinically isolated syndrome patients were followed over a median period of 2.9 years (range 1.6–4.6 years) and underwent 3T magnetic resonance imaging including 3D susceptibility weighted imaging and T2-weighted fluid-attenuated inversion recovery. We assessed the presence of susceptibility weighted imaging hypointense core or ring lesions, and Expanded Disability Status Scale at baseline and follow-up. ## Results Of 611 lesions at baseline, 64 (10.5%) had a susceptibility weighted imaging hypointense core, and 28 (4.6%) had a susceptibility weighted imaging hypointense ring. Hypointense ring lesions were larger (__p__ < 0.001) and more T1w hypointense (__p__ = 0.002) than others. During follow-up, hypointense core lesions became susceptibility weighted imaging isointense (52 lesions, 81%); few de

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Author

Nelly Blindenbacher; Eveline Brunner; Susanna Asseyer; Michael Scheel; Nadja Siebert; Ludwig Rasche; Judith Bellmann-Strobl; Alexander Brandt; Klemens Ruprecht; Dominik Meier; Jens Wuerfel; Friedemann Paul; Tim Sinnecker

Publisher

SAGE Publications

Published

2020

Language

EN

Field

Medicine (Health Sciences)